Ferrous Glycinate

Ferrous glycinate is a chemical compound that is a chelated form of iron, consisting of ferrous ions (Fe²⁺) bound to the amino acid glycine. This chelation forms a stable complex that improves iron’s solubility and bioavailability, making ferrous glycinate an effective and well-tolerated dietary supplement for treating iron deficiency and anemia. It is usually a light greenish or grey-green powder, soluble in water but practically insoluble in organic solvents. The chelate protects the iron ion from reactions in the gastrointestinal tract that can limit absorption, and it is less likely to cause gastrointestinal side effects compared to other iron supplements. Ferrous glycinate is commonly used in nutritional formulations, fortified foods, and pharmaceuticals due to its high efficacy and safety profile in promoting iron levels in the body.

Appearance: Grey-green to dark green, free-flowing fine powder; sometimes tan to brown, hygroscopic (absorbs moisture easily).
Solubility: Soluble in water, practically insoluble in acetone and ethanol.
Melting Point: Decomposes above 162°C

Ferrous glycinate is a chelated form of iron used primarily as a dietary supplement and food fortificant to treat and prevent iron deficiency anemia. Nutritionally, it provides iron that has high bioavailability and is well-absorbed even in the presence of dietary inhibitors like phytate. Studies indicate that iron from ferrous glycinate is absorbed more efficiently than from ferrous sulfate, and it is regulated by the body’s iron status to prevent overload.

Ferrous glycinate benefits as an iron supplement include:

• High bioavailability: Ferrous glycinate is more efficiently absorbed than traditional iron salts like ferrous sulfate, which means lower doses can achieve the same therapeutic effect.

• Reduced gastrointestinal side effects: It causes fewer stomach issues such as nausea, constipation, or gastric irritation compared to other iron supplements, improving patient compliance.

• Effective treatment of iron deficiency anemia: It increases hemoglobin concentrations and replenishes iron stores effectively in various populations including pregnant women, adolescents, and children.

• Better tolerance in pregnancy: Studies show it improves iron status with fewer adverse events during pregnancy compared to ferrous sulfate.

• Supports energy and immunity: By improving iron levels, it enhances oxygen transport and reduces symptoms of fatigue and weakness, contributing to overall well-being and immune support.

• Stable and safe form: The chelated form is more stable at stomach pH and less likely to interact with dietary inhibitors